Prion protein interconversions and the transmissible spongiform encephalopathies

被引：82

作者：

Horiuchi, M ^{[1
]}

Caughey, B ^{[1
]}

机构：

[1] NIAID, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA

来源：

STRUCTURE | 1999年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0969-2126(00)80049-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autocatalytic changes in the conformation and aggregation state of prion protein appear to be fundamental to transmissible spongiform encephalopathies or prion diseases. Here we review the considerable progress that has been made in describing the normal properties of prion protein and the changes that occur during these devastating neurodegenerative diseases.

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页码：R231 / R240

页数：10

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