Cancer stem cell markers in common cancers - therapeutic implications

被引：309

作者：

Klonisch, Thomas ^{[1
]}

Wiechec, Emilia ^{[2
]}

Hombach-Kionisch, Sabine ^{[1
]}

Ande, Sudharsana R. ^{[3
,4
]}

Wesselborg, Sebastian ^{[5
]}

Schulze-Osthoff, Klaus ^{[6
]}

Los, Marek ^{[1
,3
,4
]}

机构：

[1] Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0W3, Canada

[2] Univ Aarhus, Inst Human Genet, DK-8000 Aarhus, Denmark

[3] CancerCare Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada

[4] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3E 0W3, Canada

[5] Univ Tubingen, Dept Internal Med 1, D-72076 Tubingen, Germany

[6] Univ Tubingen, Interfac Inst Biochem, D-72076 Tubingen, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.molmed.2008.08.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid advances in the cancer stem cell (CSC) field have provided cause for optimism for the development of more reliable cancer therapies in the future. Strategies aimed at efficient targeting of CSCs are becoming important for monitoring the progress of cancer therapy and for evaluating new therapeutic approaches. Here, we characterize and compare the specific markers that have been found to be present on stem cells, cancer cells and CSCs in selected tissues (colon, breast, liver, pancreas and prostate). We then discuss future directions of this intriguing new research field in the context of new diagnostic and therapeutic opportunities.

引用

页码：450 / 460

页数：11

共 118 条

[11] Characterization of benign and malignant prostate epithelial Hoechst 33342 side populations [J].