Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells

被引:22
作者
Aprea, Julieta
Calegari, Federico [1 ]
机构
[1] Tech Univ Dresden, DFG Res Ctr, Fac Med, D-01307 Dresden, Germany
关键词
GATED ION CHANNELS; PROGENITOR CELLS; GABA(A) RECEPTOR; NMDA RECEPTORS; COTRANSPORTER EXPRESSION; DEPENDENT CLEAVAGE; POTASSIUM CHANNELS; ELECTRICAL-FIELDS; AMPA RECEPTORS; NEURONS ARISE;
D O I
10.1155/2012/816049
中图分类号
Q813 [细胞工程];
学科分类号
摘要
The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem cells. The importance of understanding stem cell contribution to tissue formation during embryonic development, adult homeostasis, and regeneration in disease has prompted many groups to study and manipulate the membrane potential of stem cells in a variety of systems. In this paper we aimed at summarizing the current knowledge on the role of ion channels and pumps in the context of mammalian corticogenesis with particular emphasis on their contribution to the switch of neural stem cells from proliferation to differentiation and generation of more committed progenitors and neurons, whose lineage during brain development has been recently elucidated.
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页数:10
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共 106 条
[1]   H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration [J].
Adams, Dany S. ;
Masi, Alessio ;
Levin, Michael .
DEVELOPMENT, 2007, 134 (07) :1323-1335
[2]   Activation of the GABA(A) receptor inhibits the proliferative effects of bFGF in cortical progenitor cells [J].
Antonopoulos, J ;
Pappas, IS ;
Parnavelas, JG .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (02) :291-298
[3]   Neural stem and progenitor cells shorten S-phase on commitment to neuron production [J].
Arai, Yoko ;
Pulvers, Jeremy N. ;
Haffner, Christiane ;
Schilling, Britta ;
Nuesslein, Ina ;
Calegari, Federico ;
Huttner, Wieland B. .
NATURE COMMUNICATIONS, 2011, 2
[4]   Generation and Analysis of a Mouse Line Harboring GFP in the Eomes/Tbr2 Locus [J].
Arnold, Sebastian J. ;
Sugnaseelan, Jacintha ;
Groszer, Matthias ;
Srinivas, Shankar ;
Robertson, Elizabeth J. .
GENESIS, 2009, 47 (11) :775-781
[5]   Live Imaging at the Onset of Cortical Neurogenesis Reveals Differential Appearance of the Neuronal Phenotype in Apical versus Basal Progenitor Progeny [J].
Attardo, Alessio ;
Calegari, Federico ;
Haubensak, Wulf ;
Wilsch-Braeuninger, Michaela ;
Huttner, Wieland B. .
PLOS ONE, 2008, 3 (06)
[6]   Voltage-gated currents, dye and electrical coupling in the embryonic mouse neocortex [J].
Bahrey, HLP ;
Moody, WJ .
CEREBRAL CORTEX, 2003, 13 (03) :239-251
[7]   Bioelectric controls of cell proliferation Ion channels, membrane voltage and the cell cycle [J].
Blackiston, Douglas J. ;
McLaughlin, Kelly A. ;
Levin, Michael .
CELL CYCLE, 2009, 8 (21) :3527-3536
[8]   Ion pumps [J].
Blostein, R. .
CURRENT OPINION IN CELL BIOLOGY, 1989, 1 (04) :746-752
[9]  
Borgens R B, 1988, Adv Neurol, V47, P51
[10]   ELECTROLYTES AND WATER IN BRAIN AND CEREBROSPINAL-FLUID OF FETAL SHEEP AND GUINEA-PIG [J].
BRADBURY, MW ;
SAUNDERS, NR ;
DESAI, S ;
REYNOLDS, M ;
REYNOLDS, JM ;
CROWDER, J .
JOURNAL OF PHYSIOLOGY-LONDON, 1972, 227 (02) :591-+