Synthesis of a homotrifunctional conjugation reagent based on maleimide chemistry

被引：12

作者：

Farha, OK ^{[1
]}

Julius, RL ^{[1
]}

Hawthorne, MF ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 15期

基金：

美国国家科学基金会;

关键词：

maleimide; cysteine; Diels-Alder; Mitsunobu; thiol; homotrifunctional conjugation reagent; 1,3,5-tris(hydroxymethyl)benzene; 1,3,5-tris-(N-maleimidomethyl)benzene;

D O I：

10.1016/j.tetlet.2006.02.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel homotrifunctional conjugation reagent, 1, 3,5-tris-(N-maleimidomethyl) benzene has been synthesized in high yield with minimum purification. The reactivity of this compound was examined by using L-cysteine as a nucleophile. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2619 / 2622

页数：4

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