Back-to-back ''one-pot'' [F-18]FDG syntheses in a single Siemens-CTI chemistry process control unit

被引：8

作者：

Mock, BH

Vavrek, MT

Mulholland, GK

机构：

[1] Department of Radiology, Indiana Univ. School of Medicine, Indianpolis, IN 46202-5121, 975 West Walnut St.

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 04期

关键词：

F-18]FDG; positron emission tomography; radiochemistry; tetramethylammonium;

D O I：

10.1016/0969-8051(96)00030-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

Simple changes in the chemistry, plumbing, and programming of the Siemens CTI chemistry process control unit (CPCU) effectively double its output by enabling two back-to back ''1-pot'' syntheses of 2-[F-18]fluoro-2-deoxy-D-glucose in a single unit. Replacement of Kryptofix 2.2.2 with tetramethylammonium carbonate and elimination of diethyl ether from the procedure shorten synthesis time to 48 min, improve process and end product safety, and increase end-of-synthesis yields from 37% to 52% by minimizing steps and transfer losses.

引用

页码：497 / 501

页数：5

共 13 条

[1]

EFFECT OF A DIAZA-POLYOXA-MACROBICYCLIC COMPLEXING AGENT ON URINARY ELIMINATION OF LEAD IN LEAD-POISONED RATS [J].