Monitoring chemical reactions by using ion-channel-forming peptides

被引：30

作者：

Blake, S

Mayer, T

Mayer, M

Yang, J

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 03期

关键词：

biotechnology; gramicidin A; membranes; self-assembly; sensors;

D O I：

10.1002/cbic.200500532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current affairs. We demonstrate that it is possible to detect the conversion of reactive chemical groups on molecules attached to gramicidin A in the presence of external chemical reagents, such as KNO2, by monitoring the change in single-channel conductances across planar lipid bilayers. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：433 / 435

页数：3

共 50 条

[1]

Aidley DJ., 1996, ION CHANNELS MOL ACT

[2]

[Anonymous], 2001, ANGEW CHEM, V113, P1790

[3] EFFECTS OF SURFACE-CHARGE ON THE CONDUCTANCE OF THE GRAMICIDIN CHANNEL [J].