Terminology and classification of the cortical dysplasias

被引:756
作者
Palmini, A
Najm, I
Avanzini, G
Babb, T
Guerrini, R
Foldvary-Schaefer, N
Jackson, G
Lüders, HO
Prayson, R
Spreafico, R
Vinters, HV
机构
[1] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil
[2] Cleveland Clin Fdn, Cleveland, OH 44195 USA
[3] Ist Nazl Neurol Carlo Besta, Milan, Italy
[4] Wayne State Univ, Detroit, MI USA
[5] Univ Pisa, Ist Neuropsichiatria Infantile, I-56100 Pisa, Italy
[6] Austin Hosp, Melbourne, Vic 3084, Australia
[7] Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA
关键词
D O I
10.1212/01.WNL.0000114507.30388.7E
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: There have been difficulties in achieving a uniform terminology in the literature regarding issues of classification with respect to focal cortical dysplasias (FCDs) associated with epilepsy. Objectives: To review and refine the current terminology and classification issues of potential clinical relevance to epileptologists, neuroradiologists, and neuropathologists dealing with FCD. Methods: A panel discussion of epileptologists, neuropathologists, and neuroradiologists with special expertise in FCD was held. Results: The panel proposed 1) a specific terminology for the different types of abnormal cells encountered in the cerebral cortex of patients with FCD; 2) a reappraisal of the different histopathologic abnormalities usually subsumed under the term "microdysgenesis," and suggested that this terminology be abandoned; and 3) a more detailed yet straightforward classification of the various histopathologic features that usually are included under the heterogeneous term of "focal cortical dysplasia." Conclusion: The panel hopes that these proposals will stimulate the debate toward more specific clinical, imaging, histopathologic, and prognostic correlations in patients with FCD associated with epilepsy.
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收藏
页码:S2 / S8
页数:7
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