Enhancing immunity to HIV through APOBEC

被引：41

作者：

Harris, Reuben ^{[1
,2
]}

机构：

[1] Univ Minnesota, Inst Mol Virol, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Beckman Ctr Genome Engn, Minneapolis, MN 55455 USA

来源：

NATURE BIOTECHNOLOGY | 2008年 / 26卷 / 10期

关键词：

D O I：

10.1038/nbt1008-1089

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A small molecule that interferes with HIV Vif promotes the antiviral activity of the human protein APOBEC3G.

引用

页码：1089 / 1090

页数：2

共 15 条

[1] Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G [J].

Hache, Guylaine ;

Shindo, Keisuke ;

Albin, John S. ;

Harris, Reuben S. .

CURRENT BIOLOGY, 2008, 18 (11) :819-824

[2] DNA determination mediates innate immunity to retroviral infection [J].

Harris, RS ;

Bishop, KN ;

Sheehy, AM ;

Craig, HM ;

Petersen-Mahrt, SK ;

Watt, IN ;

Neuberger, MS ;

Malim, MH .

CELL, 2003, 113 (06) :803-809

[3] RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators [J].

Harris, RS ;

Petersen-Mahrt, SK ;

Neuberger, MS .

MOLECULAR CELL, 2002, 10 (05) :1247-1253

[4] Lethal mutagenesis of HIV with mutagenic nucleoside analogs [J].

Loeb, LA ;

Essigmann, JM ;

Kazazi, F ;

Zhang, J ;

Rose, KD ;

Mullins, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1492-1497

[5] Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts [J].

Mangeat, B ;

Turelli, P ;

Caron, G ;

Friedli, M ;

Perrin, L ;

Trono, D .

NATURE, 2003, 424 (6944) :99-103

[6] Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 vif and inhibitors of Vif-APOBEC3G binding [J].

Mehle, Andrew ;

Wilson, Heather ;

Zhang, Chengsheng ;

Brazier, Andrew Jay ;

McPike, Mark ;

Pery, Erez ;

Gabuzda, Dana .

JOURNAL OF VIROLOGY, 2007, 81 (23) :13235-13241

[7] Cytidine deamination induced HIV-1 drug resistance [J].

Mulder, Lubbertus C. F. ;

Harari, Ariana ;

Simon, Viviana .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (14) :5501-5506

[8] Small-molecule inhibition of HIV-1 Vif [J].

Nathans, Robin ;

Cao, Hong ;

Sharova, Natalia ;

Ali, Akbar ;

Sharkey, Mark ;

Stranska, Ruzena ;

Stevenson, Mario ;

Rana, Tariq M. .

NATURE BIOTECHNOLOGY, 2008, 26 (10) :1187-1192

[9] Transcriptional regulation of APOBEC3G, a cytidine deaminase that hypermutates human immunodeficiency virus [J].

Rose, KM ;

Marin, M ;

Kozak, SL ;

Kabat, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (40) :41744-41749

[10] APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast [J].

Schumacher, AJ ;

Nissley, DV ;

Harris, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (28) :9854-9859

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