Aging and the immune system

被引：24

作者：

Gorczynski, Reginald M. ^{[1
]}

Terzioglu, Ender ^{[2
]}

机构：

[1] Univ Hlth Network, Toronto Hosp, Toronto, ON, Canada

[2] Akdeniz Univ, Dept Med, TR-07058 Antalya, Turkey

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2008年 / 40卷 / 04期

关键词：

Immunosenescence; Aging; Inflammation; Immunoregulation;

D O I：

10.1007/s11255-008-9412-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is associated with many physiological changes in a variety of organ systems. Nevertheless, considerable interest has centred on the possibility that age-related immunological changes may play a key "master" role in regulating many, if not all, subsequent events. A growing body of data, some of it highlighted in this review, supports the notion that host resistance in general is changed in both a qualitative and quantitative manner with age, though the biochemical mechanism(s) underlying such changes are not unique to the immune system per se. Moreover, interventions designed to explore treatments which may reverse some or all of those age-related changes have pointed out a fundamentally important role for nutrition, and the way(s) in which this impacts on host resistance mechanism(s), as having a hitherto unappreciated importance in immunosenescence in general.

引用

页码：1117 / 1125

页数：9

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