Aging and the immune system

被引：24

作者：

Gorczynski, Reginald M. ^{[1
]}

Terzioglu, Ender ^{[2
]}

机构：

[1] Univ Hlth Network, Toronto Hosp, Toronto, ON, Canada

[2] Akdeniz Univ, Dept Med, TR-07058 Antalya, Turkey

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2008年 / 40卷 / 04期

关键词：

Immunosenescence; Aging; Inflammation; Immunoregulation;

D O I：

10.1007/s11255-008-9412-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is associated with many physiological changes in a variety of organ systems. Nevertheless, considerable interest has centred on the possibility that age-related immunological changes may play a key "master" role in regulating many, if not all, subsequent events. A growing body of data, some of it highlighted in this review, supports the notion that host resistance in general is changed in both a qualitative and quantitative manner with age, though the biochemical mechanism(s) underlying such changes are not unique to the immune system per se. Moreover, interventions designed to explore treatments which may reverse some or all of those age-related changes have pointed out a fundamentally important role for nutrition, and the way(s) in which this impacts on host resistance mechanism(s), as having a hitherto unappreciated importance in immunosenescence in general.

引用

页码：1117 / 1125

页数：9

共 87 条

[41] Inflammatory mediators in the elderly [J].

Krabbe, KS ;

Pedersen, M ;

Bruunsgaard, H .

EXPERIMENTAL GERONTOLOGY, 2004, 39 (05) :687-699

[42] The role of IL-10 and TGF-β in the differentiation and effector function of T regulatory cells [J].

Levings, MK ;

Bacchetta, R ;

Schulz, U ;

Roncarolo, MG .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2002, 129 (04) :263-276

[43] High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain [J].

Lin, MT ;

Simon, DK ;

Ahn, CH ;

Kim, LM ;

Beal, MF .

HUMAN MOLECULAR GENETICS, 2002, 11 (02) :133-145

[44] Effect of aging on macrophage function [J].

Lloberas, J ;

Celada, A .

EXPERIMENTAL GERONTOLOGY, 2002, 37 (12) :1325-1331

[45]

Maletto B, 2002, J LEUKOCYTE BIOL, V72, P447

[46] CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice [J].

Manning, BM ;

Enioutina, EY ;

Visic, DM ;

Knudson, AD ;

Daynes, RA .

EXPERIMENTAL GERONTOLOGY, 2001, 37 (01) :107-126

[47] RANTES and MIP-1α production by T lymphocytes, monocytes and NK cells from nonagenarian subjects [J].

Mariani, E ;

Pulsatelli, L ;

Neri, S ;

Dolzani, P ;

Meneghetti, A ;

Silvestri, T ;

Ravaglia, G ;

Forti, P ;

Cattini, L ;

Facchini, A .

EXPERIMENTAL GERONTOLOGY, 2002, 37 (2-3) :219-226

[48] A single dose of vitamin D enhances immunity to mycobacteria [J].

Martineau, Adrian R. ;

Wilkinson, Robert J. ;

Wilkinson, Katalin A. ;

Newton, Sandra M. ;

Kampmann, Beate ;

Hall, Bridget M. ;

Packe, Geoffrey E. ;

Davidson, Robert N. ;

Eldridge, Sandra M. ;

Maunsell, Zoe J. ;

Rainbow, Sandra J. ;

Berry, Jacqueline L. ;

Griffiths, Christopher J. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 176 (02) :208-213

[49] Age-related changes in eosinophil function in human subjects [J].

Mathur, Sameer K. ;

Schwantes, Elizabeth A. ;

Jarjour, Nizar N. ;

Busse, William W. .

CHEST, 2008, 133 (02) :412-419

[50] Effect of aging on T lymphocyte activation [J].

Miller, RA .

VACCINE, 2000, 18 (16) :1654-1660

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