Targeting the minor groove of DNA

被引：192

作者：

Wemmer, DE ^{[1
]}

Dervan, PB ^{[1
]}

机构：

[1] CALTECH,DIV CHEM & CHEM ENGN,PASADENA,CA 91125

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(97)80051-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome will be useful tools in molecular biology and, potentially, in human medicine. Pairing rules have been developed to control rationally the sequence specifity of minor groove binding polyamides containing N-methylimidazole and N-methylpyrrole amino acids. Using simple molecular shapes and a two-letter aromatic amino acid code, pyrrole-imidazole polyamides achieve affinities and specificities comparable to DNA-binding proteins. (C) Current Biology Ltd.

引用

页码：355 / 361

页数：7

共 47 条

[41] DESIGN OF PEPTIDES THAT BIND IN THE MINOR GROOVE OF DNA AT 5'-(A,T)G(A,T)C(A,T)-3' SEQUENCES BY A DIMERIC SIDE-BY-SIDE MOTIF [J].