Plant viral suppressors of RNA silencing

被引：258

作者：

Roth, BM ^{[1
]}

Pruss, GJ ^{[1
]}

Vance, VB ^{[1
]}

机构：

[1] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA

来源：

VIRUS RESEARCH | 2004年 / 102卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RNA silencing; RNAi; viral suppressor protein; HC-Pro; CMV; 2b;

D O I：

10.1016/j.virusres.2004.01.020

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA silencing is an ancient eukaryotic pathway in which double stranded RNA (dsRNA) triggers destruction of related RNAs in the cell. Early Studies in plants pointed to a role for this pathway as a defense against Viruses. Most known plant viruses have RNA genomes and replicate via dsRNA intermediates, thereby serving as potent inducers of RNA silencing early in replication and as silencing targets later in infection. Because RNA silencing is an antiviral mechanism, it is not surprising that many plant viruses encode suppressors of RNA silencing, This review focuses on the currently known plant virus encoded Suppressors of silencing and the functional assays used to identify these proteins. Because they interfere with silencing at different points in the pathway, these viral suppressors are Powerful tools to help unravel the mechanism of RNA silencing in plants. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：97 / 108

页数：12

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