p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD

被引：49

作者：

Banerjee, Audreesh ^{[1
]}

Koziol-White, Cynthia ^{[1
]}

Panettieri, Reynold, Jr. ^{[1
]}

机构：

[1] Hosp Univ Penn, Dept Med, Airways Biol Initiat, Div Pulm Allergy & Crit Care Med, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 03期

关键词：

ACTIVATED PROTEIN-KINASE; OBSTRUCTIVE PULMONARY-DISEASE; NF-KAPPA-B; CIGARETTE-SMOKE; INDUCED SPUTUM; INFLAMMATION; PATHWAY; TARGET; INFLIXIMAB; EXPRESSION;

D O I：

10.1016/j.coph.2012.01.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

COPD represents a major respiratory disorder, causing significant morbidity and mortality throughout the world. While therapies exist for COPD, they are not always effective, and many patients experience exacerbations and morbidity despite current therapies. Study of the molecular mechanisms involved in the underlying physiological manifestations of COPD has yielded multiple new targets for therapeutic intervention. In this review, we discuss signaling pathways involved in COPD pathogenesis and review clinical studies of p38 MAPK inhibitors, TNF alpha inhibitors, and IKK2 inhibitors as potential COPD therapies.

引用

页码：287 / 292

页数：6

共 48 条

[21] NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract [J].

Liu, Xiangde ;

Togo, Shinsaku ;

Al-Mugotir, Mona ;

Kim, Huijung ;

Fang, QiuHong ;

Kobayashi, Tetsu ;

Wang, XingQi ;

Mao, Lijun ;

Bitterman, Peter ;

Rennard, Stephen .

RESPIRATORY RESEARCH, 2008, 9 (1)

[22] TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water [J].

Matera, Maria Gabriella ;

Calzetta, Luigino ;

Cazzola, Mario .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2010, 23 (02) :121-128

[23] p38α-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation [J].

Medicherla, Satyanarayana ;

Fitzgerald, Mary F. ;

Spicer, Dianne ;

Woodman, Paul ;

Ma, Jing Y. ;

Kapoun, Ann M. ;

Chakravarty, Sarvajit ;

Dugar, Sundeep ;

Protter, Andrew A. ;

Higgins, Linda S. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 324 (03) :921-929

[24] Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease [J].

Millan, David S. ;

Bunnage, Mark E. ;

Burrows, Jane L. ;

Butcher, Kenneth J. ;

Dodd, Peter G. ;

Evans, Timothy J. ;

Fairman, David A. ;

Hughes, Samantha J. ;

Kilty, Iain C. ;

Lemaitre, Arnaud ;

Lewthwaite, Russell A. ;

Mahnke, Axel ;

Mathias, John P. ;

Philip, James ;

Smith, Robert T. ;

Stefaniak, Mark H. ;

Yeadon, Michael ;

Phillips, Christopher .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (22) :7797-7814

[25] Role of TNFα in pulmonary pathophysiology [J].

Mukhopadhyay, Srirupa ;

Hoidal, John R. ;

Mukherjee, Tapan K. .

RESPIRATORY RESEARCH, 2006, 7 (1)

[26]

Nakamura H, 2002, IN VIVO, V16, P45

[27] LPS response and endotoxin tolerance in Flt-3L-induced bone marrow-derived dendritic cells [J].

Patenaude, Julie ;

D'Elia, Michele ;

Cote-Maurais, Guillaume ;

Bernier, Jacques .

CELLULAR IMMUNOLOGY, 2011, 271 (01) :184-191

[28] Small Molecule p38 MAP Kinase Inhibitors for the Treatment of Inflammatory Diseases: Novel Structures and Developments During 2006-2008 [J].

Pettus, Liping H. ;

Wurz, Ryan P. .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (16) :1452-1467

[29] Oxidative stress and redox regulation of lung inflammation in COPD [J].

Rahman, I. ;

Adcock, I. M. .

EUROPEAN RESPIRATORY JOURNAL, 2006, 28 (01) :219-242

[30] Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke [J].

Rajendrasozhan, Saravanan ;

Hwang, Jae-Woong ;

Yao, Hongwei ;

Kishore, Nandini ;

Rahman, Irfan .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2010, 23 (03) :172-181

← 1 2 3 4 5 →