Kinamycin biosynthesis. Synthesis, isolation, and incorporation of stealthin C, an aminobenzo[b]fluorene

被引：92

作者：

Gould, SJ

Melville, CR

Cone, MC

Chen, J

Carney, JR

机构：

[1] Department of Chemistry, Oregon State University, Corvallis

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 02期

关键词：

D O I：

10.1021/jo961486y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new intermediate in the biosynthesis of the benzo[b]fluorene antibiotic, kinamycin D, has been identified. 11-Amino-4,5,9-trihydroxy-2-methyl-10H-benzo[b]fluoren-10-one was synthesized and shown to be present in extracts of treptomyces murayamaensis fermentations. A deuterated sample was prepared and shown to be specifically incorporated into kinamycin D. This new intermediate, now named stealthin C, is also the probable hydroxylation substrate for the biosynthesis of stealthin A by S. Viridochromogenes.

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页码：320 / 324

页数：5

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