Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

被引:263
作者
Brown, Solange P. [1 ]
Hestrin, Shaul [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Comparat Med, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
VISUAL-CORTEX; LAYER-V; CORTICOSTRIATAL NEURONS; SYNAPTIC CONNECTIONS; PROJECTION NEURONS; MORPHOLOGY; CELLS; CORTICOPONTINE; ORGANIZATION; PATTERNS;
D O I
10.1038/nature07658
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cortical columns generate separate streams of information that are distributed to numerous cortical and subcortical brain regions(1). We asked whether local intracortical circuits reflect these different processing streams by testing whether the intracortical connectivity among pyramidal neurons reflects their long-range axonal targets. We recorded simultaneously from up to four retrogradely labelled pyramidal neurons that projected to the superior colliculus, the contralateral striatum or the contralateral cortex to assess their synaptic connectivity. Here we show that the probability of synaptic connection depends on the functional identities of both the presynaptic and postsynaptic neurons. We first found that the frequency of monosynaptic connections among corticostriatal pyramidal neurons is significantly higher than among corticocortical or corticotectal pyramidal neurons. We then show that the probability of feed-forward connections from corticocortical neurons to corticotectal neurons is approximately three- to four-fold higher than the probability of monosynaptic connections among corticocortical or corticotectal cells. Moreover, we found that the average axodendritic overlap of the presynaptic and postsynaptic pyramidal neurons could not fully explain the differences in connection probability that we observed. The selective synaptic interactions we describe demonstrate that the organization of local networks of pyramidal cells reflects the long-range targets of both the presynaptic and postsynaptic neurons.
引用
收藏
页码:1133 / U89
页数:5
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