Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: A reconsideration

被引：32

作者：

Borowitz, Drucy ^{[1
]}

Gelfond, Daniel ^{[1
]}

Maguiness, Karen ^{[2
]}

Heubi, James E. ^{[3
,4
]}

Ramsey, Bonnie ^{[5
]}

机构：

[1] SUNY Buffalo, Sch Med & Biomed Sci, Women & Childrens Hosp Buffalo, Dept Pediat, Buffalo, NY 14222 USA

[2] Indiana Univ Hlth, Riley Hosp Children, Indianapolis, IN USA

[3] Cincinnati Childrens Med Ctr, Cincinnati, OH 45229 USA

[4] Univ Cincinnati, Dept Pediat, Cincinnati, OH 45221 USA

[5] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

来源：

JOURNAL OF CYSTIC FIBROSIS | 2013年 / 12卷 / 06期

关键词：

Pancreatic insufficiency; Pancreatic enzymes; Cystic fibrosis; Infant nutrition; INSUFFICIENCY; MANAGEMENT; NUTRITION; CHILDREN; GROWTH;

D O I：

10.1016/j.jcf.2013.05.011

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The current recommendations for dosing of pancreatic enzyme replacement therapy (PERT) in infants with cystic fibrosis (CF) were made using a limited evidence base. The per meal recommended dose was extrapolated from dosing guidelines for older patients into a maximal daily dose for infants. We discuss why this maximal daily dose recommendation may be insufficient for young infants with CF, although the optimal dose of PERT for infants with CF remains unknown. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier BAT. All rights reserved.

引用

页码：784 / 785

页数：2

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