Myosin light chain kinase: pulling the strings of epithelial tight junction function

被引：258

作者：

Cunningham, Kevin E. ^{[1
]}

Turner, Jerrold R. ^{[1
]}

机构：

[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

BARRIERS AND CHANNELS FORMED BY TIGHT JUNCTION PROTEINS II | 2012年 / 1258卷

关键词：

tight junction; myosin light chain kinase; TNF-alpha; inflammatory bowel disease; INCREASED INTESTINAL PERMEABILITY; INFLAMMATORY-BOWEL-DISEASE; MEMBRANE-PERMEANT PEPTIDE; NECROSIS-FACTOR-ALPHA; ACTIN-BINDING REGION; DIARRHEA IN-VIVO; BARRIER DYSFUNCTION; PHYSIOLOGICAL REGULATION; GLUCOSE-TRANSPORT; CROHNS-DISEASE;

D O I：

10.1111/j.1749-6632.2012.06526.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dynamic regulation of paracellular permeability is essential for physiological epithelial function, while dysregulated permeability is commonindisease. The recent elucidationof themolecular compositionof the epithelial tight junction complex has been accompanied by characterization of diverse intracellular mediators of paracellular permeabiltiy. Myosin light chain kinase (MLCK), which induces contraction of the perijunctional actomyosin ring throughmyosin II regulatory light chain phosphorylation, has emerged as a key regulator of tight junction permeability. Examination of the regulation and role of MLCK in tight junction dysfunction has helped to define pathological processes and characterize the role of barrier loss in disease pathogenesis, and may provide future therapeutic targets to treat intestinal disease.

引用

页码：34 / 42

页数：9

共 72 条

[71] Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability [J].