α-Synuclein: The Long Distance Runner

被引：109

作者：

George, Sonia ^{[1
]}

Rey, Nolwen L. ^{[1
]}

Reichenbach, Nicole ^{[1
]}

Steiner, Jennifer A. ^{[2
]}

Brundin, Patrik ^{[1
,2
]}

机构：

[1] Lund Univ, Neuronal Survival Unit, Wallenberg Neurosci Ctr, Lund, Sweden

[2] Ctr Neurodegenerat Sci, Van Andel Res Inst, Grand Rapids, MI 49503 USA

来源：

BRAIN PATHOLOGY | 2013年 / 23卷 / 03期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

alpha-Synuclein; Lewy pathology; Parkinson's disease; prion disease; prion-like aggregation; templated misfolding; PARKINSONS-DISEASE PATHOLOGY; TO-NEURON TRANSMISSION; SLOW AXONAL-TRANSPORT; DOPAMINERGIC-NEURONS; LEWY BODIES; AGGREGATION; CLEARANCE; MUTATIONS; OLIGOMERS; FIBRILS;

D O I：

10.1111/bpa.12046

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Parkinson's disease is characterized by -synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak etal described the spatial and temporal spread of -synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that -synuclein can transfer from cell to cell. In this review, we highlight the involvement of -synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of -synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of -synuclein and focus our review on the long-distance axonal transport of -synuclein along neurons.

引用

收藏

页码：350 / 357

页数：8

相关论文

共 78 条

[1]

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Schapira, Anthony H. ;

Gardiner, Chris ;

Sargent, Ian L. ;

Wood, Matthew J. A. ;

Cooper, J. Mark .

NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :360-367

[2]

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo [J].

Angot, Elodie ;

Steiner, Jennifer A. ;

Tome, Carla M. Lema ;

Ekstrom, Peter ;

Mattsson, Bengt ;

Bjorklund, Anders ;

Brundin, Patrik .

PLOS ONE, 2012, 7 (06)

[3]

Antibody-Aided Clearance of Extracellular α-Synuclein Prevents Cell-to-Cell Aggregate Transmission [J].

Bae, Eun-Jin ;

Lee, He-Jin ;

Rockenstein, Edward ;

Ho, Dong-Hwan ;

Park, Eun-Bi ;

Yang, Na-Young ;

Desplats, Paula ;

Masliah, Eliezer ;

Lee, Seung-Jae .

JOURNAL OF NEUROSCIENCE, 2012, 32 (39) :13454-13469

[4]

α-synuclein is expressed in different tissues during human fetal development [J].

Baltic, S ;

Perovic, M ;

Mladenovic, A ;

Raicevic, N ;

Ruzdijic, S ;

Rakic, L ;

Kanazir, S .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2004, 22 (03) :199-203

[5]

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation [J].

Bartels, Tim ;

Choi, Joanna G. ;

Selkoe, Dennis J. .

NATURE, 2011, 477 (7362) :107-U123

[6]

Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen [J].

Braak, H ;

Rüb, U ;

Gai, WP ;

Del Tredici, K .

JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (05) :517-536

[7]

Research in motion: the enigma of Parkinson's disease pathology spread [J].

Brundin, Patrik ;

Li, Jia-Yi ;

Holton, Janice L. ;

Lindvall, Olle ;

Revesz, Tamas .

NATURE REVIEWS NEUROSCIENCE, 2008, 9 (10) :741-745

[8]

A Critical Evaluation of the Braak Staging Scheme for Parkinson's Disease [J].

Burke, Robert E. ;

Dauer, William T. ;

Vonsattel, Jean Paul G. .

ANNALS OF NEUROLOGY, 2008, 64 (05) :485-491

[9]

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro [J].

Burre, Jacqueline ;

Sharma, Manu ;

Tsetsenis, Theodoros ;

Buchman, Vladimir ;

Etherton, Mark R. ;

Suedhof, Thomas C. .

SCIENCE, 2010, 329 (5999) :1663-1667

[10]

α-synuclein locus duplication as a cause of familial Parkinson's disease [J].

Chartier-Harlin, MC ;

Kachergus, J ;

Roumier, C ;

Mouroux, V ;

Douay, X ;

Lincoln, S ;

Levecque, C ;

Larvor, L ;

Andrieux, J ;

Hulihan, M ;

Waucquier, N ;

Defebvre, L ;

Amouyel, P ;

Farrer, M ;

Destée, A .

LANCET, 2004, 364 (9440) :1167-1169

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