Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis

被引：67

作者：

Chang, Chi-Ching ^{[2
,5
]}

Hsieh, Ming-Shium ^{[3
,4
]}

Liao, Say-Tsung ^{[2
]}

Chen, Yi-Hsuan ^{[1
]}

Cheng, Chao-Wen ^{[5
]}

Huang, Pai-Tsang ^{[6
]}

Lin, Yung-Feng ^{[1
]}

Chen, Chien-Ho ^{[1
]}

机构：

[1] Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Taipei, Taiwan

[2] Taipei Med Univ Hosp, Dept Internal Med, Div Rheumatol Immunol & Allergy, Taipei, Taiwan

[3] En Chu Kong Hosp, Dept Orthoped, New Taipei, Taiwan

[4] Taipei Med Univ, Sch Med, Taipei, Taiwan

[5] Taipei Med Univ, Grad Inst Clin Med, Taipei, Taiwan

[6] Wan Fang Hosp, Dept Occupat Med, Taipei, Taiwan

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 02期

关键词：

Hyaluronan; Osteoarthritis; Peroxisome proliferator-activated receptor; Cyclooxygenase-2; Matrix metalloproteinase; NF-KAPPA-B; MOLECULAR-WEIGHT HYALURONAN; ACTIVATED PROTEIN-KINASES; MESSENGER-RNA EXPRESSION; ARTICULAR CHONDROCYTES; MAP KINASE; SYNOVIAL FIBROBLASTS; PATHWAYS; ACID; CARTILAGE;

D O I：

10.1016/j.carbpol.2012.06.071

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The carbohydrate polymer, hyaluronan, is a major component of the extracellular matrix in animal tissues. Exogenous hyaluronan has been used to treat osteoarthritis (OA), a degenerative joint disease involving inflammatory changes. The underlying mechanisms of hyaluronan in OA are not fully understood. Pro-inflammatory interleukin (IL)-1 beta downregulates peroxisome proliferator-activated receptor gamma (PPAR gamma), and increases expression of matrix metalloproteinases (MMPs) which are responsible for the degeneration of articular cartilage. The effects of low- and high-molecular-weight hyaluronan (oligo-HA and HMW-HA) on the inflammatory genes were determined in human SW-1353 chondrosarcoma cells. HMW-HA antagonized the effects of IL-1 beta by increasing PPAR gamma and decreasing cyclooxygenase (COX)-2. MMP-1, and MMP-13 levels. It promoted Akt, but suppressed mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF kappa B) signaling, indicating anti-inflammatory effects. In contrast, the cells had overall opposite responses to oligo-HA. In conclusion, HMW-HA and oligo-HA exerted differential inflammatory responses via PPAR gamma in IL-1 beta-treated chondrosarcoma cells. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1168 / 1175

页数：8

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