Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth

被引：45

作者：

Lewis, RE

Lo, HJ

Raad, II

Kontoyiannis, DP

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Infect Dis, Houston, TX 77030 USA

[2] Univ Houston, Coll Pharm, Houston, TX 77204 USA

[3] Natl Hlth Res Inst, Taipei, Taiwan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 04期

关键词：

D O I：

10.1128/AAC.46.4.1153-1155.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.

引用

页码：1153 / 1155

页数：3

共 9 条

[1] FONZI WA, 1993, GENETICS, V134, P717
[2] Signal transduction cascades regulating fungal development and virulence
Lengeler, KB
Davidson, RC
D'Souza, C
Harashima, T
Shen, WC
Wang, P
Pan, XW
Waugh, M
Heitman, J
[J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (04) : 746 - +
[3] SUPPRESSION OF HYPHAL FORMATION IN CANDIDA-ALBICANS BY MUTATION OF A STE12 HOMOLOG
LIU, HP
KOHLER, J
FINK, GR
[J]. SCIENCE, 1994, 266 (5191) : 1723 - 1726
[4] Nonfilamentous C-albicans mutants are avirulent
Lo, HJ
Kohler, JR
DiDomenico, B
Loebenberg, D
Cacciapuoti, A
Fink, GR
[J]. CELL, 1997, 90 (05) : 939 - 949
[5] Nosocomial candidiasis: Emerging species, reservoirs, and modes of transmission
Pfaller, MA
[J]. CLINICAL INFECTIOUS DISEASES, 1996, 22 : S89 - S94
[6] Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture
Riggle, FJ
Andrutis, KA
Chen, X
Tzipori, SR
Kumamoto, CA
[J]. INFECTION AND IMMUNITY, 1999, 67 (07) : 3649 - 3652
[7] ADHERENCE OF CANDIDA SPECIES TO INTRAVENOUS CATHETERS
ROTROSEN, D
GIBSON, TR
EDWARDS, JE
[J]. JOURNAL OF INFECTIOUS DISEASES, 1983, 147 (03) : 594 - 594
[8] 3-YEAR EXPERIENCE WITH SONICATED VASCULAR CATHETER CULTURES IN A CLINICAL MICROBIOLOGY LABORATORY
SHERERTZ, RJ
RAAD, II
BELANI, A
KOO, LC
RAND, KH
PICKETT, DL
STRAUB, SA
FAUERBACH, LL
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (01) : 76 - 82
[9] Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi
Stoldt, VR
Sonneborn, A
Leuker, CE
Ernst, JF
[J]. EMBO JOURNAL, 1997, 16 (08) : 1982 - 1991

← 1 →