Broadly Neutralizing Antiviral Antibodies

被引：360

作者：

Corti, Davide ^{[1
,2
]}

Lanzavecchia, Antonio ^{[1
,3
]}

机构：

[1] Inst Res Biomed IRB, CH-6500 Bellinzona, Switzerland

[2] Humabs BioMed SA, CH-6500 Bellinzona, Switzerland

[3] ETH, Inst Microbiol, CH-8092 Zurich, Switzerland

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷

关键词：

variability; protection; vaccines; HIV-1; influenza; dengue; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; HUMAN MONOCLONAL-ANTIBODIES; PROXIMAL EXTERNAL REGION; INFLUENZA-A VIRUS; HEMAGGLUTININ-SPECIFIC ANTIBODIES; CROSS-REACTIVE ANTIBODIES; B-CELL RESPONSES; HIV-1; VACCINE; IN-VITRO;

D O I：

10.1146/annurev-immunol-032712-095916

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive immune response. The widely held view has been that the great variability of viral glycoproteins would be an absolute obstacle to the development of antibody-based therapies or vaccines that could confer broad and long-lasting protection. In the past five years, new approaches have been developed to interrogate human memory B cells and plasma cells with high efficiency and to isolate several broadly neutralizing antiviral antibodies against highly variable pathogens such as HIV-1 and influenza virus. These antibodies not only provide new tools for prophylaxis and therapy for viral diseases but also identify conserved epitopes that may be used to design new vaccines capable of conferring broader protection.

引用

页码：705 / 742

页数：38

共 219 条

[1] Duration of humoral immunity to common viral and vaccine antigens [J].

Amanna, Ian J. ;

Carlson, Nichole E. ;

Slifka, Mark K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (19) :1903-1915

[2] CELLULAR PROTEINS BOUND TO IMMUNODEFICIENCY VIRUSES - IMPLICATIONS FOR PATHOGENESIS AND VACCINES [J].

ARTHUR, LO ;

BESS, JW ;

SOWDER, RC ;

BENVENISTE, RE ;

MANN, DL ;

CHERMANN, JC ;

HENDERSON, LE .

SCIENCE, 1992, 258 (5090) :1935-1938

[3] Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold [J].

Azoitei, Mihai L. ;

Correia, Bruno E. ;

Ban, Yih-En Andrew ;

Carrico, Chris ;

Kalyuzhniy, Oleksandr ;

Chen, Lei ;

Schroeter, Alexandria ;

Huang, Po-Ssu ;

McLellan, Jason S. ;

Kwong, Peter D. ;

Baker, David ;

Strong, Roland K. ;

Schief, William R. .

SCIENCE, 2011, 334 (6054) :373-376

[4] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].

Baba, TW ;

Liska, V ;

Hofmann-Lehmann, R ;

Vlasak, J ;

Xu, WD ;

Ayehunie, S ;

Cavacini, LA ;

Posner, MR ;

Katinger, H ;

Stiegler, G ;

Bernacky, BJ ;

Rizvi, TA ;

Schmidt, R ;

Hill, LR ;

Keeling, ME ;

Lu, YC ;

Wright, JE ;

Chou, TC ;

Ruprecht, RM .

NATURE MEDICINE, 2000, 6 (02) :200-206

[5] Antibody-based protection against HIV infection by vectored immunoprophylaxis [J].

Balazs, Alejandro B. ;

Chen, Joyce ;

Hong, Christin M. ;

Rao, Dinesh S. ;

Yang, Lili ;

Baltimore, David .

NATURE, 2012, 481 (7379) :81-U88

[6] Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates [J].

Baldanti, F. ;

Paolucci, S. ;

Campanini, G. ;

Sarasini, A. ;

Percivalle, E. ;

Revello, M. G. ;

Gerna, G. .

ARCHIVES OF VIROLOGY, 2006, 151 (06) :1225-1233

[7] Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification [J].

Balsitis, Scott J. ;

Williams, Katherine L. ;

Lachica, Ruben ;

Flores, Diana ;

Kyle, Jennifer L. ;

Mehlhop, Erin ;

Johnson, Syd ;

Diamond, Michael S. ;

Beatty, P. Robert ;

Harris, Eva .

PLOS PATHOGENS, 2010, 6 (02)

[8] Revisiting the role of neutralizing antibodies in mother-to-child transmission of HIV-1 [J].

Barin, F ;

Jourdain, G ;

Brunet, S ;

Ngo-Giang-Huong, N ;

Weerawatgoompa, S ;

Karnchanamayul, W ;

Ariyadej, S ;

Hansudewechakul, R ;

Achalapong, J ;

Yuthavisuthi, P ;

Ngampiyaskul, C ;

Bhakeecheep, S ;

Hemwutthiphan, C ;

Lallemant, M .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (11) :1504-1511

[9] Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against Influenza A M2 protein [J].

Beerli, Roger R. ;

Bauer, Monika ;

Schmitz, Nicole ;

Buser, Regula B. ;

Gwerder, Myriam ;

Muntwiler, Simone ;

Renner, Wolfgang A. ;

Saudan, Philippe ;

Bachmann, Martin F. .

VIROLOGY JOURNAL, 2009, 6

[10] The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity [J].

Beltramello, Martina ;

Williams, Katherine L. ;

Simmons, Cameron P. ;

Macagno, Annalisa ;

Simonelli, Luca ;

Quyen, Nguyen Than Ha ;

Sukupolvi-Petty, Soila ;

Navarro-Sanchez, Erika ;

Young, Paul R. ;

de Silva, Aravinda M. ;

Rey, Felix A. ;

Varani, Luca ;

Whitehead, Stephen S. ;

Diamond, Michael S. ;

Harris, Eva ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

CELL HOST & MICROBE, 2010, 8 (03) :271-283

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