Inhibition of Borna disease virus replication by ribavirin

被引：39

作者：

Jordan, I

Briese, T

Averett, DR

Lipkin, WI ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Neurol, Lab Study Emerging Dis, Irvine, CA 92697 USA

[2] ICN Pharmaceut Inc, Costa Mesa, CA 92626 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 09期

关键词：

D O I：

10.1128/JVI.73.9.7903-7906.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The guanosine analogue ribavirin was tested for antiviral activity in two neural cell lines, human oligodendrocytes and rat glia, against Borna disease virus (BDV) strains V and He/80. Ribavirin treatment resulted in lower levels of virus and viral transcripts within 12 h. Addition of guanosine but not adenosine resulted in a profound reduction of the ribavirin effect. Ribavirin appears to be an effective antiviral agent for treatment of BDV infection in vitro. A likely mechanism for its activity is reduction of the intracellular GTP pool, resulting in inhibition of transcription and capping of BDV mRNAs.

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页码：7903 / 7906

页数：4

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