Models of experimental bacterial meningitis - Role and limitations

被引:41
作者
Koedel, U [1 ]
Pfister, HW [1 ]
机构
[1] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany
关键词
D O I
10.1016/S0891-5520(05)70094-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The seriousness of bacterial meningitis has encouraged the development of animal models that characterize complex pathogenetic and pathophysiologic mechanisms, provide evaluation of pharmacokinetic and antimicrobial effects of antibiotics (especially since the worldwide emergence of multiresistant bacteria), and establish new adjuvant treatment strategies (e.g., use of antiinflammatory agents). The information obtained from an animal model depends on the site of inoculation. For example, using intranasal, intravenous, subcutaneous, or intraperitoneal inoculation, it is the bacterial and host factors that determine the development of bacteremia and the potential for a pathogen to invade the central nervous system that primarily are studied. In contrast, experimental models using direct inoculation into the cerebrospinal fluid can reliably produce lethal infections over a predictable time course. Furthermore, because adult animals will not reliably develop meningitis after intranasal or intraperitoneal challenge, infant animals are used. Because these models bypass the natural dissemination of bacteria from the intravascular compartment to the central nervous system, the pathogenesis is artificial. These models, however, are extremely useful for the study of pathogen and host factors leading to meningeal inflammation and resulting complications, and for evaluating potentially useful agents for treatment therapy During the past decade, the design of clinical studies has been stimulated by findings obtained from these animal models.
引用
收藏
页码:549 / +
页数:30
相关论文
共 182 条
  • [61] LANDING BH, 1960, POSTGRAD MED, V33, P248
  • [62] DEXAMETHASONE THERAPY FOR BACTERIAL-MENINGITIS - RESULTS OF 2 DOUBLE-BLIND, PLACEBO-CONTROLLED TRIALS
    LEBEL, MH
    FREIJ, BJ
    SYROGIANNOPOULOS, GA
    CHRANE, DF
    HOYT, MJ
    STEWART, SM
    KENNARD, BD
    OLSEN, KD
    MCCRACKEN, GH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (15) : 964 - 971
  • [63] Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis
    Leib, SL
    Kim, YS
    Black, SM
    Tureen, JH
    Täuber, MG
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (03) : 692 - 700
  • [64] Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis
    Leib, SL
    Kim, YS
    Ferriero, DM
    Tauber, MG
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (01) : 166 - 171
  • [65] Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
    Leib, SL
    Kim, YS
    Chow, LL
    Sheldon, RA
    Tauber, MG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (11) : 2632 - 2639
  • [66] TUMOR NECROSIS FACTOR-ALPHA IN CEREBROSPINAL-FLUID DURING BACTERIAL, BUT NOT VIRAL, MENINGITIS - EVALUATION IN MURINE MODEL INFECTIONS AND IN PATIENTS
    LEIST, TP
    FREI, K
    KAMHANSEN, S
    ZINKERNAGEL, RM
    FONTANA, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (05) : 1743 - 1748
  • [68] DETAILED DESCRIPTION OF A CRANIAL WINDOW TECHNIQUE FOR ACUTE AND CHRONIC EXPERIMENTS
    LEVASSEUR, JE
    WEI, EP
    RAPER, AJ
    KONTOS, HA
    PATTERSON, JL
    [J]. STROKE, 1975, 6 (03) : 308 - 317
  • [69] VALIDATION OF LASER-DOPPLER FLOWMETRY IN MEASUREMENT OF SPINAL-CORD BLOOD-FLOW
    LINDSBERG, PJ
    ONEILL, JT
    PAAKKARI, IA
    HALLENBECK, JM
    FEUERSTEIN, G
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (02): : H674 - H680
  • [70] LIU VC, 1992, BACTERIAL MENINGITIS, P30