HIV-1 Vif versus APOBEC3G: newly appreciated warriors in the ancient battle between virus and host

被引：7

作者：

Argyris, EG ^{[1
]}

Pomerantz, RJ ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Div Infect Dis & Environm Med, Ctr Human Virol & Biodef,Dorrance H Hamilton Labs, Philadelphia, PA 19107 USA

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 04期

关键词：

D O I：

10.1016/j.tim.2004.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies demonstrate that apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), the newly identified target of HIV-1 Vif, represents an endogenous inhibitor of HIV-1 replication and is a viral-encapsidated cellular protein that deaminates minus-strand reverse transcript cytosine residues to uracils. HIV-1 Vif counteracts the inhibitory activity of APOBEC3G by forming a complex with the enzyme, inducing its degradation and preventing its viral encapsidation. This finding provides valuable insights into virus-host interactions and suggests a potential, novel anti-HIV-1 therapeutic approach.

引用

页码：145 / 148

页数：4

共 24 条

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