Diverse Sequence Types of Klebsiella pneumoniae Contribute to the Dissemination of blaNDM-1 in India, Sweden, and the United Kingdom

被引：160

作者：

Giske, Christian G. ^{[1
]}

Froding, Inga ^{[1
]}

Hasan, Chowdhury Mehedi ^{[1
]}

Turlej-Rogacka, Agata ^{[1
,2
]}

Toleman, Mark ^{[3
]}

Livermore, David ^{[4
,5
]}

Woodford, Neil ^{[4
]}

Walsh, Timothy R. ^{[3
,6
]}

机构：

[1] Karolinska Univ Hosp, Karolinska Inst MTC, Stockholm, Sweden

[2] Natl Med Inst, Div Clin Microbiol & Infect Prevent, Warsaw, Poland

[3] Cardiff Univ, Cardiff, S Glam, Wales

[4] Hlth Protect Agcy, Antibiot Resistance Monitoring & Reference Lab, London, England

[5] Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England

[6] Univ Queensland, Clin Res Ctr, Herston, Qld, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 05期

关键词：

ESCHERICHIA-COLI; IDENTIFICATION; CARBAPENEMASES; PCR;

D O I：

10.1128/AAC.06142-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clinical isolates of Klebsiella pneumoniae producing NDM-1 carbapenemase from India (n = 22), the United Kingdom (n = 13), and Sweden (n = 4) were subjected to multilocus sequence typing (MLST), automated repetitive sequence-based PCR (rep-PCR), serotyping, virulence gene screening, and plasmid replicon typing. The most frequently detected MLST sequence types (STs) were ST14 (n = 13; all serotype K2), ST11, ST149, ST231, and ST147. The correlation between MLST and automated rep-PCR was excellent. IncA/C was the most frequently detected plasmid replicon type (n = 14). ST14, ST11, and other successful clones may be important for the dissemination of bla(NDM-1).

引用

页码：2735 / 2738

页数：4

共 10 条

[1] Virulent Clones of Klebsiella pneumoniae: Identification and Evolutionary Scenario Based on Genomic and Phenotypic Characterization [J].

Brisse, Sylvain ;

Fevre, Cindy ;

Passet, Virginie ;

Issenhuth-Jeanjean, Sylvie ;

Tournebize, Regis ;

Diancourt, Laure ;

Grimont, Patrick .

PLOS ONE, 2009, 4 (03)

[2] The DiversiLab system versus pulsed-field gel electrophoresis: Characterisation of extended spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae [J].

Brolund, Alma ;

Haeggman, Sara ;

Edquist, Petra J. ;

Gezelius, Lena ;

Olsson-Liljequist, Barbro ;

Wisell, Karin Tegmark ;

Giske, Christian G. .

JOURNAL OF MICROBIOLOGICAL METHODS, 2010, 83 (02) :224-230

[3] Identification of plasmids by PCR-based replicon typing [J].

Carattoli, A ;

Bertini, A ;

Villa, L ;

Falbo, V ;

Hopkins, KL ;

Threlfall, EJ .

JOURNAL OF MICROBIOLOGICAL METHODS, 2005, 63 (03) :219-228

[4] Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study [J].

Kumarasamy, Karthikeyan K. ;

Toleman, Mark A. ;

Walsh, Timothy R. ;

Bagaria, Jay ;

Butt, Fafhana ;

Balakrishnan, Ravikumar ;

Chaudhary, Uma ;

Doumith, Michel ;

Giske, Christian G. ;

Irfan, Seema ;

Krishnan, Padma ;

Kumar, Anil V. ;

Maharjan, Sunil ;

Mushtaq, Shazad ;

Noorie, Tabassum ;

Paterson, David L. ;

Pearson, Andrew ;

Perry, Claire ;

Pike, Rachel ;

Rao, Bhargavi ;

Ray, Ujjwayini ;

Sarma, Jayanta B. ;

Sharma, Madhu ;

Sheridan, Elizabeth ;

Thirunarayan, Mandayam A. ;

Turton, Jane ;

Upadhyay, Supriya ;

Warner, Marina ;

Welfare, William ;

Livermore, David M. ;

Woodford, Neil .

LANCET INFECTIOUS DISEASES, 2010, 10 (09) :597-602

[5] Phylogenetic diversity of Escherichia coli strains producing NDM-type carbapenemases [J].

Mushtaq, S. ;

Irfan, S. ;

Sarma, J. B. ;

Doumith, M. ;

Pike, R. ;

Pitout, J. ;

Livermore, D. M. ;

Woodford, N. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (09) :2002-2005

[6] NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman [J].

Poirel, Laurent ;

Al Maskari, Zaina ;

Al Rashdi, Fatma ;

Bernabeu, Sandrine ;

Nordmann, Patrice .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (02) :304-306

[7] Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance [J].

Samuelsen, O. ;

Toleman, M. A. ;

Hasseltvedt, V. ;

Fuursted, K. ;

Leegaard, T. M. ;

Walsh, T. R. ;

Sundsfjord, A. ;

Giske, C. G. .

CLINICAL MICROBIOLOGY AND INFECTION, 2011, 17 (12) :1811-1816

[8] Evaluation of a multiplex PCR for detection of serotypes K1, K2 and K5 in Klebsiella sp and comparison of isolates within these serotypes [J].

Turton, Jane F. ;

Baklan, Hatice ;

Siu, L. K. ;

Kaufmann, Mary E. ;

Pitt, Tyrone L. .

FEMS MICROBIOLOGY LETTERS, 2008, 284 (02) :247-252

[9] Emerging carbapenemases: a global perspective [J].

Walsh, Timothy R. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2010, 36 :S8-S14

[10] Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance [J].

Woodford, Neil ;

Turton, Jane F. ;

Livermore, David M. .

FEMS MICROBIOLOGY REVIEWS, 2011, 35 (05) :736-755

← 1 →