Emerging carbapenemases: a global perspective

被引：360

作者：

Walsh, Timothy R. ^{[1
]}

机构：

[1] Cardiff Univ, Sect Med Microbiol IIB, Sch Med Sci, Heath Pk Hosp, Cardiff CF14 4XN, S Glam, Wales

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2010年 / 36卷

基金：

英国惠康基金;

关键词：

Carbapenemases; Metallo-beta-lactamases; Carbapenem resistance; METALLO-BETA-LACTAMASE; RESISTANT ACINETOBACTER-BAUMANNII; KLEBSIELLA-PNEUMONIAE; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; SERRATIA-MARCESCENS; BACTERIAL PATHOGENS; BALANCING SCIENCE; CLINICAL ISOLATE; CLONAL SPREAD;

D O I：

10.1016/S0924-8579(10)70004-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-beta-lactamase variants. In particular, the media attention given to the NDM-1 metallo-beta-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：S8 / S14

页数：7

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