Emerging carbapenemases: a global perspective

被引:360
作者
Walsh, Timothy R. [1 ]
机构
[1] Cardiff Univ, Sect Med Microbiol IIB, Sch Med Sci, Heath Pk Hosp, Cardiff CF14 4XN, S Glam, Wales
基金
英国惠康基金;
关键词
Carbapenemases; Metallo-beta-lactamases; Carbapenem resistance; METALLO-BETA-LACTAMASE; RESISTANT ACINETOBACTER-BAUMANNII; KLEBSIELLA-PNEUMONIAE; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; SERRATIA-MARCESCENS; BACTERIAL PATHOGENS; BALANCING SCIENCE; CLINICAL ISOLATE; CLONAL SPREAD;
D O I
10.1016/S0924-8579(10)70004-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-beta-lactamase variants. In particular, the media attention given to the NDM-1 metallo-beta-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:S8 / S14
页数:7
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