Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of Acinetobacter baumanni

被引：358

作者：

Mugnier, Pauline D.

Poirel, Laurent

Naas, Thierry

Nordmann, Patrice

机构：

[1] INSERM, U914, Paris, France

[2] Univ Paris Sud, Le Kremlin Bicetre, France

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 01期

关键词：

RESISTANT; STRAINS; SALMONELLA; EMERGENCE; OUTBREAK; SPREAD;

D O I：

10.3201/eid1601.090852

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To assess dissemination of OXA-23-producing strains of Acinetobacter baumannii, we obtained 20 carbapenem-resistant, OXA-23-producing isolates from different regions. Their clonal relationship was assessed by pulsed-field gel electrophoresis and multilocus sequence typing. We identified 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European clonal lineages. The bla(OXA-23) gene was either located on the chromosome or on plasmids and associated with 4 genetic structures.

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页码：35 / 40

页数：6

相关论文

共 25 条

[1] Genetic Basis of Multidrug Resistance in Acinetobacter baumannii Clinical Isolates at a Tertiary Medical Center in Pennsylvania [J].

Adams-Haduch, Jennifer M. ;

Paterson, David L. ;

Sidjabat, Hanna E. ;

Pasculle, Anthony W. ;

Potoski, Brian A. ;

Muto, Carlene A. ;

Harrison, Lee H. ;

Doi, Yohei .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (11) :3837-3843

[2] Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii [J].

Bartual, SG ;

Seifert, H ;

Hippler, C ;

Luzon, MAD ;

Wisplinghoff, H ;

Rodríguez-Valera, F .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (09) :4382-4390

[3] Carbapenem-Resistant Acinetobacter baumannii Isolates Expressing the blaOXA-23 Gene Associated with ISAba4 in Belgium [J].

Bogaerts, Pierre ;

Cuzon, Gaelle ;

Naas, Thierry ;

Bauraing, Caroline ;

Deplano, Ariane ;

Lissoir, Benedicte ;

Nordmann, Patrice ;

Glupczynski, Youri .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (11) :4205-4206

[4] Multidrug-resistant organisms in military wounds from iraq and afghanistan [J].

Calhoun, Jason H. ;

Murray, Clinton K. ;

Manring, M. M. .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2008, 466 (06) :1356-1362

[5] Dissemination of multidrug-resistant Acinetobacter baumannii genotypes carrying blaOXA-23 collected from hospitals in Rio de Janeiro, Brazil [J].

Carvalho, Karyne Rangel ;

D'Alincourt Carvalho-Assef, Ana Paula ;

Peirano, Gisele ;

Galvao dos Santos, Lia Cristina ;

Felix Pereira, Maria Jose ;

Asensi, Marise Dutra .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2009, 34 (01) :25-28

[6]

Clinical and Laboratory Standards Institute, 2008, M100S18 CLIN LAB STA

[7] Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii [J].

Corvec, Stephane ;

Poirel, Laurent ;

Naas, Thierry ;

Drugeon, Henri ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (04) :1530-1533

[8] Bacterial identification, clinical significance, and antimicrobial susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri, two frequently misidentified opportunistic pathogens [J].

Dortet, Laurent ;

Legrand, Patrick ;

Soussy, Claude-James ;

Cattoir, Vincent .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (12) :4471-4478

[9] GENOMIC MAPPING WITH I-CEU I, AN INTRON-ENCODED ENDONUCLEASE SPECIFIC FOR GENES FOR RIBOSOMAL-RNA, IN SALMONELLA SPP, ESCHERICHIA-COLI, AND OTHER BACTERIA [J].

LIU, SL ;

HESSEL, A ;

SANDERSON, KE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6874-6878

[10] Carbapenem-resistant and OXA-23-producing Acinetobacter baumannii isolates in the United Arab Emirates [J].

Mugnier, P. ;

Poirel, L. ;

Pitout, M. ;

Nordmann, P. .

CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 (09) :879-882