Carbapenem-resistant and OXA-23-producing Acinetobacter baumannii isolates in the United Arab Emirates

被引：31

作者：

Mugnier, P. ^{[1
,2
]}

Poirel, L. ^{[1
,2
]}

Pitout, M. ^{[3
]}

Nordmann, P. ^{[1
,2
]}

机构：

[1] Hop Bicetre, AP HP, Serv Bacteriol Virol, INSERM,U Emerging Resistance Antibiot 914,Fac Med, F-94275 Le Kremlin Bicetre, France

[2] Univ Paris Sud, Le Kremlin Bicetre, France

[3] Sheikh Khalifa Med City, Dept Microbiol, Abu Dhabi, U Arab Emirates

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2008年 / 14卷 / 09期

关键词：

Acinetobacter baumannii; carbapenem resistance; OXA-23; transposon; United Arab Emirates;

D O I：

10.1111/j.1469-0691.2008.02056.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Five carbapenem-resistant Acinetobacter baumannii isolates, collected from the United Arab Emirates in 2006, were investigated to identify the mechanism(s) responsible for carbapenem resistance. Genotyping was performed by pulsed-field gel electrophoresis, and the location of the bla(OXA-23) gene was determined by using the endonuclease I CeuI technique and mating-out assays. The four isolates in which the bla(OXA-23) gene was located on the chromosome within a Tn2006 composite transposon were clonally related. The single non-clonally related isolate harboured the bla(OXA-23) gene on a 70-kb transferable plasmid. This study reports on the dissemination of OXA-23-producing A. baumannii isolates in the Middle East.

引用

页码：879 / 882

页数：5

共 15 条

[1]

Clinical and Laboratory Standards Institute, 2007, M100S17 CLSI S

[2] Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii [J].

Corvec, Stephane ;

Poirel, Laurent ;

Naas, Thierry ;

Drugeon, Henri ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (04) :1530-1533

[3] Sequence analysis of ARI-1, a novel OXA β-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92 [J].

Donald, HM ;

Scaife, W ;

Amyes, SGB ;

Young, HK .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (01) :196-199

[4] Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii [J].

Héritier, C ;

Poirel, L ;

Nordmann, P .

CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 (02) :123-130

[5] Phylogenetic relationship of the twenty-one DNA groups of the genus Acinetobacter as revealed by 16S ribosomal DNA sequence analysis [J].

Ibrahim, A ;

GernerSmidt, P ;

Liesack, W .

INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1997, 47 (03) :837-841

[6] GENOMIC MAPPING WITH I-CEU I, AN INTRON-ENCODED ENDONUCLEASE SPECIFIC FOR GENES FOR RIBOSOMAL-RNA, IN SALMONELLA SPP, ESCHERICHIA-COLI, AND OTHER BACTERIA [J].

LIU, SL ;

HESSEL, A ;

SANDERSON, KE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6874-6878

[7] OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa [J].

Philippon, LN ;

Naas, T ;

Bouthors, AT ;

Barakett, V ;

Nordmann, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) :2188-2195

[8] Carbapenem resistance in Acinetobacter baumannii:: mechanisms and epidemiology [J].

Poirel, L. ;

Nordmann, P. .

CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 (09) :826-836

[9] Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype Typhimurium DT104 from French patients [J].

Poirel, L ;

Guibert, M ;

Bellais, S ;

Naas, T ;

Nordmann, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) :1098-1104

[10] Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp. [J].

Poirel, Laurent ;

Figueiredo, Samy ;

Cattoir, Vincent ;

Carattoli, Alessandra ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (04) :1252-1256

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