Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.
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作者:
Poirel, Laurent
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Univ Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, FranceUniv Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, France
Poirel, Laurent
[1
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Figueiredo, Samy
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Univ Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, FranceUniv Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, France
Figueiredo, Samy
[1
]
Cattoir, Vincent
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Univ Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, FranceUniv Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, France
Cattoir, Vincent
[1
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Carattoli, Alessandra
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Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, ItalyUniv Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, France
Carattoli, Alessandra
[2
]
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Nordmann, Patrice
[1
]
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[1] Univ Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, France
[2] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy
Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla(OXA-23) oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla(OXA-23)-Iike genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla(OXA-23)-Iike genes. A similar plasmid backbone was identified in several bla(OXA-23)-positive A. baumannii and A. radioresistens isolates, further strengthening the vectors of exchanges for these bla(OXA-23)-like genes. Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla(OXA-23) gene.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
Berlau J.
Aucken H.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
Aucken H.
Malnick H.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
Malnick H.
Pitt T.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
机构:
Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
Berlau J.
Aucken H.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
Aucken H.
Malnick H.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT
Malnick H.
Pitt T.
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Central Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HTCentral Public Health Laboratory, Laboratory of Hospital Infection, London NW9 5HT