Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.

被引:168
作者
Poirel, Laurent [1 ]
Figueiredo, Samy [1 ]
Cattoir, Vincent [1 ]
Carattoli, Alessandra [2 ]
Nordmann, Patrice [1 ]
机构
[1] Univ Paris 11, Hop Bicetre, INSERM U914, Serv Bacteriol Virol,AP HP, F-94275 Le Kremlin Bicetre, France
[2] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy
关键词
D O I
10.1128/AAC.01304-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla(OXA-23) oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla(OXA-23)-Iike genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla(OXA-23)-Iike genes. A similar plasmid backbone was identified in several bla(OXA-23)-positive A. baumannii and A. radioresistens isolates, further strengthening the vectors of exchanges for these bla(OXA-23)-like genes. Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla(OXA-23) gene.
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页码:1252 / 1256
页数:5
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