Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii

被引：181

作者：

Corvec, Stephane

Poirel, Laurent

Naas, Thierry

Drugeon, Henri

Nordmann, Patrice

机构：

[1] Hop Bicetre, Serv Bacteriol Virol, Assistance Publ Hop Paris, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

[2] CHU, Lab Bacteriol Virol Hyg Hosp, Nantes, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期

关键词：

BETA-LACTAMASE; OXA-23; RESISTANCE; INSERTION; OUTBREAK; TRANSPOSITION; BLA(CTX-M); ISABA1; AMPC;

D O I：

10.1128/AAC.01132-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genetic structures surrounding the plasmid-carried bla(OXA-23) oxacillinase gene, encoding resistance to carbapenems, were studied in Acinetobacter baumannii. ISAba1 and the novel element ISAba4 were detected upstream of the bla(OXA-23) gene, providing promoter sequences for its expression. These insertion elements were likely involved in transposition processes at the origin of acquisition of this beta-lactamase gene.

引用

页码：1530 / 1533

页数：4

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