Towards an HIV cure: a global scientific strategy

被引:430
作者
Deeks, Steven G. [1 ]
机构
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
CD4(+) T-CELLS; IMMUNODEFICIENCY-VIRUS TYPE-1; RALTEGRAVIR INTENSIFICATION; ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; IMMUNE ACTIVATION; ANTIVIRAL THERAPY; LATENT INFECTION; IN-VITRO; MODEL;
D O I
10.1038/nri3262
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Given the limitations of antiretroviral therapy and recent advances in our understanding of HIV persistence during effective treatment, there is a growing recognition that a cure for HIV infection is both needed and feasible. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. Several priorities for basic, translational and clinical research were identified. This Opinion article summarizes the group's recommended key goals for the international community.
引用
收藏
页码:607 / 614
页数:8
相关论文
共 80 条
  • [21] Extensive Astrocyte Infection Is Prominent in Human Immunodeficiency Virus-Associated Dementia
    Churchill, Melissa J.
    Wesselingh, Steven L.
    Cowley, Daniel
    Pardo, Carlos A.
    McArthur, Justin C.
    Brew, Bruce J.
    Gorry, Paul R.
    [J]. ANNALS OF NEUROLOGY, 2009, 66 (02) : 253 - 258
  • [22] The central nervous system as a reservoir for Simian immunodeficiency virus (SIV): Steady-state levels of SIV DNA in brain from acute through asymptomatic infection
    Clements, JE
    Babas, T
    Mankowski, JL
    Suryanarayana, K
    Piatak, M
    Tarwater, PM
    Lifson, JD
    Zink, MC
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (07) : 905 - 913
  • [23] The Emerging Race To Cure HIV Infections
    Cohen, Jon
    [J]. SCIENCE, 2011, 332 (6031) : 784 - 789
  • [24] Prevention of HIV-1 Infection with Early Antiretroviral Therapy
    Cohen, Myron S.
    Chen, Ying Q.
    McCauley, Marybeth
    Gamble, Theresa
    Hosseinipour, Mina C.
    Kumarasamy, Nagalingeswaran
    Hakim, James G.
    Kumwenda, Johnstone
    Grinsztejn, Beatriz
    Pilotto, Jose H. S.
    Godbole, Sheela V.
    Mehendale, Sanjay
    Chariyalertsak, Suwat
    Santos, Breno R.
    Mayer, Kenneth H.
    Hoffman, Irving F.
    Eshleman, Susan H.
    Piwowar-Manning, Estelle
    Wang, Lei
    Makhema, Joseph
    Mills, Lisa A.
    de Bruyn, Guy
    Sanne, Ian
    Eron, Joseph
    Gallant, Joel
    Havlir, Diane
    Swindells, Susan
    Ribaudo, Heather
    Elharrar, Vanessa
    Burns, David
    Taha, Taha E.
    Nielsen-Saines, Karin
    Celentano, David
    Essex, Max
    Fleming, Thomas R.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (06) : 493 - 505
  • [25] Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells
    Contreras, Xavier
    Schweneker, Marc
    Chen, Ching-Shih
    McCune, Joseph M.
    Deeks, Steven G.
    Martin, Jeffrey
    Peterlin, B. Matija
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (11) : 6782 - 6789
  • [26] HIV Infection, Inflammation, Immunosenescence, and Aging
    Deeks, Steven G.
    [J]. ANNUAL REVIEW OF MEDICINE, VOL 62, 2011, 2011, 62 : 141 - 155
  • [27] Human Immunodeficiency Virus Infects Human Seminal Vesicles in Vitro and in Vivo
    Deleage, Claire
    Moreau, Marina
    Rioux-Leclercq, Nathalie
    Ruffault, Annick
    Jegou, Bernard
    Dejucq-Rainsford, Nathalie
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2011, 179 (05) : 2397 - 2408
  • [28] Negative Regulation of HIV-1 Transcription by a Heterodimeric NF-κB1/p50 and C-Terminally Truncated STAT5 Complex
    Della Chiara, Giulia
    Crotti, Andrea
    Liboi, Elio
    Giacca, Mauro
    Poli, Guido
    Lusic, Marina
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2011, 410 (05) : 933 - 943
  • [29] Generation of HIV Latency in Humanized BLT Mice
    Denton, Paul W.
    Olesen, Rikke
    Choudhary, Shailesh K.
    Archin, Nancy M.
    Wahl, Angela
    Swanson, Michael D.
    Chateau, Morgan
    Nochi, Tomonori
    Krisko, John F.
    Spagnuolo, Rae Ann
    Margolis, David M.
    Garcia, J. Victor
    [J]. JOURNAL OF VIROLOGY, 2012, 86 (01) : 630 - 634
  • [30] RNA-Based Gene Therapy for HIV With Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma
    DiGiusto, David L.
    Krishnan, Amrita
    Li, Lijing
    Li, Haitang
    Li, Shirley
    Rao, Anitha
    Mi, Shu
    Yam, Priscilla
    Stinson, Sherri
    Kalos, Michael
    Alvarnas, Joseph
    Lacey, Simon F.
    Yee, Jiing-Kuan
    Li, Mingjie
    Couture, Larry
    Hsu, David
    Forman, Stephen J.
    Rossi, John J.
    Zaia, John A.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2010, 2 (36)