Circulating Fibroblast Growth Factors as Metabolic Regulators-A Critical Appraisal

被引：192

作者：

Angelin, Bo ^{[1
,2
]}

Larsson, Tobias E. ^{[3
]}

Rudling, Mats ^{[1
,2
]}

机构：

[1] Karolinska Univ, Huddinge Hosp, Karolinska Inst,Dept Med, Ctr Endocrinol Metab & Diabet,Metab Unit, S-14186 Stockholm, Sweden

[2] Karolinska Univ, Huddinge Hosp, Mol Nutr Unit, Karolinska Inst,Ctr Biosci NOVUM, S-14186 Stockholm, Sweden

[3] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol,Renal Unit, S-14186 Stockholm, Sweden

来源：

CELL METABOLISM | 2012年 / 16卷 / 06期

基金：

瑞典研究理事会;

关键词：

BILE-ACID SYNTHESIS; CHRONIC KIDNEY-DISEASE; DOMINANT HYPOPHOSPHATEMIC RICKETS; INCREASES ENERGY-EXPENDITURE; LEFT-VENTRICULAR HYPERTROPHY; FAMILIAL TUMORAL CALCINOSIS; FARNESOID-X-RECEPTOR; STAGE RENAL-DISEASE; INDUCED OBESE MICE; FACTOR; 21; FGF21;

D O I：

10.1016/j.cmet.2012.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The circulating FGFs are a new group of proteins believed to function as classic hormones. With emphasis on human metabolism, we critically review current data, and propose that-although a number of questions remain-circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation.

引用

页码：693 / 705

页数：13

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