Phosphine-catalyzed enantioselective [3+2] annulations of 2,3-butadienoates with imines

被引：120

作者：

Jean, L ^{[1
]}

Marinetti, A ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 13期

关键词：

3+2] cycloadditions; enantioselective organocatalysis; phosphines; 3-pyrrolines;

D O I：

10.1016/j.tetlet.2006.01.122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first systematic screening of chiral phosphines in the cycloaddition reaction between 2,3-butadienoates and arylimines has led to the identification of fairly efficient catalysts. 2-Aryl-3-pyrrolines have been obtained with enantiomeric excesses up to 64%. In one instance, the enantiomeric excess could be increased to 91% ee by combining the enantioselective cyclization reaction with a crystallization step. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2141 / 2145

页数：5

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