Ferrocenylphosphines as new catalysts for Baylis-Hillman reactions

被引：46

作者：

Pereira, SI

Adrio, J

Silva, AMS

Carretero, JC ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

[2] Univ Aveiro, Dept Quim, P-3810183 Aveiro, Portugal

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 24期

关键词：

D O I：

10.1021/jo051701n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Readily available ferrocenyldialkylphosphines are effective air-stable catalysts for Baylis-Hillman reaction between aldehydes and acrylates, affording the corresponding adducts in high yields and short reaction times. A set of readily accessible planar chiral ferrocenyldialkylphosphines have been tested in asymmetric Baylis-Hillman reactions. The best enantioselectivities were obtained using Mandyphos as chiral catalyst (up to 65% ee).

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页码：10175 / 10177

页数：3

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