Protein synthesis at atomic resolution: Mechanistics of translation in the light of highly resolved structures for the ribosome

被引：57

作者：

Wilson, DN ^{[1
]}

Blaha, G ^{[1
]}

Connell, SR ^{[1
]}

Ivanov, PV ^{[1
]}

Jenke, H ^{[1
]}

Stelzl, U ^{[1
]}

Teraoka, Y ^{[1
]}

Nierhaus, KH ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, AG Ribosomen, D-14195 Berlin, Germany

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2002年 / 3卷 / 01期

关键词：

D O I：

10.2174/1389203023380846

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" of functional data regarding the ribosome that has accumulated over the past decades. Here we try a systematic synopsis of these ribosomal functions in light of the cryo-electron microscopic structures (resolution >7 Angstrom) and the atomic x-ray structures (>2.4 Angstrom) of the ribosome.

引用

页码：1 / 53

页数：53

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