Donepezil in the treatment of hallucinations and delusions in Parkinson's disease

被引：106

作者：

Fabbrini, G ^{[1
]}

Barbanti, P ^{[1
]}

Aurilia, C ^{[1
]}

Pauletti, C ^{[1
]}

Lenzi, GL ^{[1
]}

Meco, G ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

来源：

NEUROLOGICAL SCIENCES | 2002年 / 23卷 / 01期

关键词：

Parkinson's disease; hallucinations; delusions; donepezil;

D O I：

10.1007/s100720200022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson's disease (PD), we conducted an open study in 8 PD patients to assess the efficacy and tolerability of the cholinesterase inhibitor donepezil, 5 mg at bedtime for two months, in the treatment of these complications. Hallucinations and delusions improved significantly in all patients. Donepezil was overall well tolerated, but a deterioration in motor disability was noted in 2 out of 8 patients.

引用

页码：41 / 43

页数：3