Studies on the active conformation of the NK1 antagonist GCP 49823 .2. Fluoro-olefin analogs of tertiary amide rotamers.

被引：15

作者：

Veenstra, SJ

Hauser, K

Felber, P

机构：

[1] Research Department, Pharmaceuticals Division, CIBA-GEIGY AG

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(96)00624-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding affinities for the NK1 receptor suggests an active conformation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent. (C) 1997, Elsevier Science Ltd.

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页码：351 / 354

页数：4

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