Long Non-Coding RNAs and p53 Regulation

被引：75

作者：

Baldassarre, Antonella ^{[1
]}

Masotti, Andrea ^{[1
]}

机构：

[1] IRCCS Bambino Gesu Childrens Hosp, Gene Express Microarrays Lab, I-00165 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 12期

关键词：

long non-coding RNAs; p53; pathway; LincRNA-p21; PANDA; H19; MEG3; LincRNA-EPS; MEG3; TRANSCRIPTION; SUPPRESSOR; EXPRESSION; REVEALS; HYPOXIA; ASC;

D O I：

10.3390/ijms131216708

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The advent of novel and high-throughput sequencing (next generation) technologies allowed for the sequencing of the genome at an unprecedented depth. The majority of transcribed RNAs have been classified as non-coding RNAs. Among them, long non-coding RNAs (lncRNAs) are emerging as important regulators in many biological processes. Here, we discuss the role of those lncRNAs which are under the control of p53 or that are able to regulate its activity, due to the central role of p53 pathway in many conditions. We also briefly discussed the emerging need of having novel strategies and computational tools to completely unravel the multifaceted roles of lncRNAs and to pave the way to the development of novel diagnostic and therapeutic applications based on these peculiar molecules.

引用

页码：16708 / 16717

页数：10

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