Palladium-Catalyzed Carboxamidation Reaction and Aldol Condensation Reaction Cascade: A Facile Approach to Ring-Fused Isoquinolinones

被引：42

作者：

Chouhan, Gagan ^{[1
]}

Alper, Howard ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ol802067y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed carboxamidation reaction and aldol condensation reaction cascade are very useful for the synthesis of various ABC ring substituted fused isoquinolinones.

引用

页码：4987 / 4990

页数：4

共 35 条

[1] Concise synthesis of 22-hydroxyacuminatine, cytotoxic camptothecinoid from Camptotheca acuminata, by pyridone benzannulation [J].

Babjak, M ;

Kanazawa, A ;

Anderson, RJ ;

Greene, AE .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (03) :407-409

[2] THE CESIUM EFFECT REVISITED [J].

BLUM, Z .

ACTA CHEMICA SCANDINAVICA, 1989, 43 (03) :248-250

[3] Synthesis of benzo[b]furans via CuI-catalyzed ring closure [J].

Chen, CY ;

Dormer, PG .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (17) :6964-6967

[4] 14-azacamptothecin: A potent water-soluble topoisomerase I poison [J].

Cheng, KJ ;

Rahier, NJ ;

Eisenhauer, BM ;

Gao, R ;

Thomas, SJ ;

Hecht, SM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (03) :838-839

[5] Palladium-catalyzed tandem Heck and aldol reactions between 2-bromobenzaldehydes and functionalized alkenes leading to naphthalenes [J].

Cho, CS ;

Lim, DK ;

Zhang, JQ ;

Kim, TJ ;

Shim, SC .

TETRAHEDRON LETTERS, 2004, 45 (29) :5653-5656

[6]

COPPOLA GM, 1981, J HETEROCYCLIC CHEM, V18, P767, DOI 10.1002/jhet.5570180427

[7] Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-Camptothecin hybrids [J].

Fox, BM ;

Xiao, XS ;

Antony, S ;

Kohlhagen, G ;

Pommier, Y ;

Staker, BL ;

Stewart, L ;

Cushman, M .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (15) :3275-3282

[8] CESIUM ION EFFECT AND MACROCYCLIZATION - A CRITICAL-REVIEW [J].

GALLI, C .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1992, 24 (03) :285-&

[9]

Heck R.F., 1985, PALLADIUM REAGENTS O

[10]

Hegedus L.S., 1999, TRANSITION METALS SY, V2nd

← 1 2 3 4 →