Progressive multifocal leukoencephalopathy in patients with rheumatic diseases: Are patients with systemic lupus erythematosus at particular risk?

被引：104

作者：

Molloy, Eamonn S. ^{[1
]}

Calabrese, Leonard H. ^{[1
]}

机构：

[1] Cleveland Clin, Cleveland, OH 44106 USA

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 8卷 / 02期

关键词：

Progressive multifocal leukoencephalopathy; Systemic lupus erythematosus; JC virus; Immunosuppressive therapy;

D O I：

10.1016/j.autrev.2008.07.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Progressive multifocal leukoencephalopathy (PML) is a rare, frequently fatal, infectious complication occurring in immunocompromised patients. PML has been well-reported in patients with chronic inflammatory rheumatic diseases taking immunosuppressive drugs. Awareness of the occurrence of PML in patients with rheumatic diseases has recently been highlighted by the occurrence of several cases of PML following administration of natalizumab and rituximab, biologic agents which have been used for the treatment of rheumatic diseases. Nearly two thirds of cases of PML in patients with rheumatic diseases reported in the medical literature occurred in patients with systemic lupus erythematosus (SLE). Over 40% of PML cases in SLE occurred in patients who had had minimal iatrogenic immunosuppression, suggesting that SLE itself may predispose to PML The mechanism of this putative predisposition of SLE patients to the development of PML remains unexplained. (C) 2008 Elsevier B.V. All rights reserved.

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收藏

页码：144 / 146

页数：3

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