Autism and familial major mood disorder: Are they related?

被引：40

作者：

DeLong, R ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Div Pediat Neurol, Dept Pediat, Durham, NC 27710 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2004年 / 16卷 / 02期

关键词：

D O I：

10.1176/appi.neuropsych.16.2.199

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Family history studies of autism consistently reveal a large subgroup with a high incidence of major mood disorder in family members, suggesting the two entities are related clinically and genetically. This review examines this concept, comparing current clinical and biological knowledge of autism and major mood disorder, and advances the hypothesis that this subgroup of autism represents an early-life phenotype of major mood disorder. If confirmed, this hypothesis would suggest that the basic biological defects determining major mood disorders may have prominent neurodevelopmental and cognitive dimensions. Testing of the hypothesis will depend on genetic studies.

引用

页码：199 / 213

页数：15

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