Selective phenol alkylation: An improved preparation of efaproxiral

被引：27

作者：

Anderson, Joanne E. ^{[1
]}

Davis, Roman ^{[1
]}

Fitzgerald, Russ N. ^{[1
]}

Haberman, Jannine M. ^{[1
]}

机构：

[1] GlaxoSmithKline Chem Dev, Res Triangle Pk, NC 27709 USA

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 15期

关键词：

Bargellini reaction; 2-bromo-2-methylpropanoic acid; efaproxiral; selective alkylation;

D O I：

10.1080/00397910600636527

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved, two-step synthesis of efaproxiral, used in breast cancer therapy, is described, utilizing inexpensive commodity chemicals for starting materials. Selective amide formation and O-alkylation in the presence of multireactive functional groups is demonstrated, thus avoiding protection/deprotection steps.

引用

页码：2129 / 2133

页数：5

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