Highly diastereoselective radical cyclizations on soluble ring opening metathesis supports

被引：29

作者：

Enholm, EJ ^{[1
]}

Cottone, JS ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 24期

关键词：

D O I：

10.1021/ol016855d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] This study represents the first examples of stereoselective radical cyclizations on soluble supports. A stereocontrol element consisting of a polymer-imbedded (+)-isosorbide chiral auxiliary was used in each monomer subunit. A survey of various Lewis acids was also examined. The best results gave very high distereoselectivites of > 100:1 in a hepa-1,3-dienenyl radical cyclization using zinc chloride as a Lewis acid.

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页码：3959 / 3962

页数：4

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