Flavonoids: Structural requirements for antiproliferative activity on breast cancer cells

被引：138

作者：

Pouget, C ^{[1
]}

Lauthier, F ^{[1
]}

Simon, A ^{[1
]}

Fagnere, C ^{[1
]}

Basly, JP ^{[1
]}

Delage, C ^{[1
]}

Chulia, AJ ^{[1
]}

机构：

[1] Fac Pharm, UPRES EA 1085, F-87025 Limoges, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)00617-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several classes of flavonoids (flavones, flavanones. 2'-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure-activity relationships of these compounds were discussed. 2'-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3095 / 3097

页数：3

共 15 条

[1] FLAVONOIDS AS DNA TOPOISOMERASE ANTAGONISTS AND POISONS - STRUCTURE-ACTIVITY-RELATIONSHIPS [J].