The major histocompatibility complex of the rat (Rattus norvegicus)

被引：98

作者：

Günther, E ^{[1
]}

Walter, L ^{[1
]}

机构：

[1] Univ Gottingen, Immungenet Abt, D-37073 Gottingen, Germany

来源：

IMMUNOGENETICS | 2001年 / 53卷 / 07期

关键词：

MHC; rat; evolution; disease models; transplantation;

D O I：

10.1007/s002510100361

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This review of the RT1 complex, the major histocompatibility complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 complex provides important information for using the rat as a model of experimental transplantation and complex diseases.

引用

页码：520 / 542

页数：23

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