A convenient iodination of indoles and derivatives

被引：17

作者：

Hamri, Salha ^{[1
]}

Rodriguez, Jose ^{[1
]}

Basset, Joan ^{[1
]}

Guillaumet, Gerald ^{[2
]}

Dolors Pujol, M. ^{[1
]}

机构：

[1] Univ Barcelona, Fac Farm, Quim Farmaceut Lab, Unitat Associada,CSIC, E-08028 Barcelona, Spain

[2] Univ Orleans, UMR CNRS 7311, Inst Chim Organ & Analyt, F-45067 Orleans, France

来源：

TETRAHEDRON | 2012年 / 68卷 / 31期

关键词：

Iodoindoles; Iodoazaindoles; Electrophilic substitution; Iodine reagents and iodination; AROMATIC IODINATION; EFFICIENT SYNTHESIS; IODINE; FUNCTIONALIZATION; MELATONIN; SERIES; MILD;

D O I：

10.1016/j.tet.2012.05.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

We report a direct iodination of indole and derivative compounds with iodine monochloride (ICI) in the presence of Celite (R). This procedure has now been extended to the iodination of substituted indoles, azaindoles and pyrroles. The scope of this procedure is exemplified by the iodination of melatonin in 98% yield. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6269 / 6275

页数：7

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