EXERCISE ATTENUATES LEVODOPA-INDUCED DYSKINESIA IN 6-HYDROXYDOPAMINE-LESIONED MICE

被引：33

作者：

Aguiar, A. S., Jr. ^{[1
,2
]}

Moreira, E. L. G. ^{[2
]}

Hoeller, A. A. ^{[1
]}

Oliveira, P. A. ^{[1
]}

Cordova, F. M. ^{[2
]}

Glaser, V. ^{[2
]}

Walz, R. ^{[3
]}

Cunha, R. A. ^{[4
,5
]}

Leal, R. B. ^{[2
]}

Latini, A. ^{[2
]}

Prediger, R. D. S. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Farmacol, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Bioquim, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Dept Ciencias Med, BR-88040900 Florianopolis, SC, Brazil

[4] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal

[5] Univ Coimbra, FMUC Fac Med, P-3004504 Coimbra, Portugal

来源：

NEUROSCIENCE | 2013年 / 243卷

关键词：

DARPP-32; dyskinesia; exercise; L-DOPA; Parkinson's disease; 6-OHDA; DOPA-INDUCED DYSKINESIA; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED MOUSE MODEL; BASAL GANGLIA INJURY; PARKINSONS-DISEASE; TREADMILL EXERCISE; FOSB EXPRESSION; BRAIN; RATS; PLASTICITY; MOTOR;

D O I：

10.1016/j.neuroscience.2013.03.039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

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页码：46 / 53

页数：8

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