The effect of n-acetylcysteine and deferoxamine on exercise-induced oxidative damage in striatum and hippocampus of mice

被引：35

作者：

Aguiar, Aderbal S., Jr. ^{[1
]}

Tuon, Talita ^{[1
]}

Soares, Fernanda S. ^{[1
]}

C. da Rocha, Luis Gustavo ^{[1
]}

Silveira, Paulo Cesar ^{[1
]}

Pinho, Ricardo A. ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Exercise Physiol Lab, PPGCS, BR-88806000 Criciuma, SC, Brazil

来源：

NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 05期

关键词：

physical exercise; oxidative stress; striatum; hippocampus; N-acetylcysteine; deferoxamine;

D O I：

10.1007/s11064-007-9485-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to analyze the effects of intense exercise on brain redox status, associated with antioxidant supplementation of N-acetylcysteine (NAC), deferoxamine (DFX) or a combination of both. Seventy-two C57BL-6 adult male mice were randomly assigned to 8 groups: control, NAC, DFX, NAC plus DFX, exercise, exercise with NAC, exercise with DFX, and exercise with NAC plus DFX. They were given antioxidant supplementation, exercise training on a treadmill for 12 weeks, and sacrificed 48 h after the last exercise session. Training significantly increased (P < 0.05) soleus citrate synthase (CS) activity when compared to control. Blood lactate levels classified the exercise as intense. Exercise significantly increased (P < 0.05) oxidation of biomolecules and superoxide dismutase activity in striatum and hippocampus. Training significantly increased (P < 0.05) catalase activity in striatum. NAC and DFX supplementation significantly protected (P < 0.05) against oxidative damage. These results indicate intense exercise as oxidant and NAC and DFX as antioxidant to the hippocampus and the striatum.

引用

页码：729 / 736

页数：8

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