Synthetic potential of heteroatomic ring systems

被引：31

作者：

Zwanenburg, B ^{[1
]}

机构：

[1] Univ Nijmegen, NSR Inst Mol Struct Design & Synth, NL-6525 ED Nijmegen, Netherlands

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 03期

关键词：

D O I：

10.1351/pac199971030423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of aziridine-2-carboxylic acid derivatives of high enantiopurity is described and their synthetic utility is discussed. Ring-opening and ring-expansion reactions of both oxirane and aziridine carboxylic esters are highlighted. Convenient syntheses of alpha-hydroxy, beta-amino and alpha-amino, beta-hydroxy carboxylic acids with defined stereochemistry are presented. The presentation of pyrrolidinone and azetidinone derivatives from functionalized three-membered heterocycles is described. Small-ring heterocycles also serve as the basis for the synthesis of catalysts, e.g. for an asymmetric reduction and for cyclopropanation reactions.

引用

页码：423 / 430

页数：8

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